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Evolution of Antibody-Drug Manufacturing

Antibody-drug Conjugates (ADCs) have evolved since the initial approval of gemtuzumab ozogamicin (Mylotarg®) in 2000, with respect to conjugation, linker and toxin chemistries and processing. With the current availability of 4 commercially approved drugs and approximately 80 programs in various clinical trials, there has been a significant interest in simplifying the complex supply chain.

With approximately 80% of the programs outsourced to Contract Development and Manufacturing Organizations (CDMOs), a transparent and integrated supply chain is critical for the success of ADC projects.

This white paper will describe how chemistry and manufacturing have evolved over the past 10 years globally and how MilliporeSigma, as a CDMO, has adapted to these changes to meet customer’s needs.

Register to download this free white paper

Learn more about:

  • how ADC manufacturing has evolved over the past decade
  • the challenges that this evolution implies
  • why the success of ADC projects are increasing tied to an integrated supply chain

Last Editorial Review: October 1, 2018

Featured Image: Scientist at MilliporeSigma Courtesy: © 2017 – 2018. Fotolia Used with permission.

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