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PEER-REVIEWED ARTICLES

Interim Phase II Results with Sacituzumab Govitecan in Pretreated Metastatic Urothelial Cancer Shows Confirmed Objective Response Rate (ORR) of 34%

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Results from an interim Phase II study with sacituzumab govitecan (IMMU-132) shows that the investigational agent is active in patients with metastatic urothelial cancer (mUC) who have relapsed or are refractory to chemotherapies and immune checkpoint inhibitors or IOs. Metastatic...

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Addressing Dendritic Cells for Anticancer Immunity

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By addressing the body’s own immune system the treatment of several severe diseases, e.g. infectious diseases, has become incredibly successful throughout the last centuries. Thus, it is highly desirable to adopt this concept to other diseases as well. Recently, cancer immunotherapy has become an alternative route to treat malignancies effectively without adverse side effects that are usually caused by classical cytostatics.

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Successful Strategies in the Development and Technology Transfer of Antibody-Drug Conjugates

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In this article, Cynthia Wooge, Ph.D., discusses the requirements of a properly designed technology transfer process and how to ensure a successful transfer and reproducible conjugation process with solid analytics, appropriate engineering design, process (quality) controls and quality assurance. She emphasizes the need to understand which details are critical and how they get effectively communicated between the various parties involved in the transfer process.

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Peer-Reviewed Articles

Registration of Antibody Drug Conjugates

14 August, 2017

Abstract      Antibody Drug Conjugates (ADC) are a rapidly expanding area of pharma company pipelines. They combine the targeting of an antibody with th...

Drugs and Drug Hunters

16 January, 2017

All products of the creative process are a reflection of the individual makeup of the inventors.  A painting by Mark Rothko looks like a Rothko painting.  A s...

When Data Integrity Takes Center Stage

10 June, 2016

1.0 Abstract Data integrity has become an important issue. To comply with regulations, companies need to optimize data integrity and the underlying strategie...


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