10 April, 2015
A few decades ago, the pharmaceutical industry developed and commercialized racemic small molecule drugs. Despite the success achieved with racemic drugs, the risk associated with the use of an enantiomer not...
Published on 10th April
A few decades ago, the pharmaceutical industry developed and commercialized racemic small molecule drugs. Despite the success achieved with racemic drugs, the risk associated with the use of an enantiomer not contributing to the therapeutic effect (but to side-effects, like in the thalidomide tragedy), combined with scientific and technical advances allowing manufacturing of enantiomerically pure drugs, have made this approach obsolete.
Currently, a racemic small molecule drug is very unlikely to get FDA approval regardless of its therapeutic properties. It is equally unlikely that a pharmaceutical company would even try to develop such a therapeutic.
Will the ADC community experience the same revolution?
The two commercial antibody-drug-conjugates, brentuximab vedotin (Adcetris®; Seattle Genetics) and ado-trastuzumab emtansine (Kadcyla®; Genentech/Roche), as well as a majority of clinical ADCs are a heterogeneous mixture of products that differ in the sites and stoichiometry of conjugation. Although they can offer improved treatments to some patient populations, heterogeneous ADCs suffer from a few drawbacks:
The emergence of site-directed conjugation techniques gives access to ADCs with improved homogeneity.  Site-directed conjugation will not only allow manufacturing of more homogeneous ADCs with optimal drug loading, it will also (or maybe first) facilitate drug development. Controlling the drug loading and conjugation site allows a comparison between homogeneous candidates, providing new learning and making ADC development less empirical.
The author believes that site-directed conjugation will ultimately result in improved standards of care and become the new gold standard for bioconjugation. This provides opportunities for patients as well as for the pharmaceutical industry.
April 10, 2015 | Corresponding Author Laurent Ducry, Ph.D | doi: 10.14229/jadc.2015.4.10.001
Received: March 29, 2015 | Published online April 10, 2015 | This submitted editorial has not been peer reviewed.
Disclosures: Laurent Ducry, Ph.D is an employee of Lonza, one of the founding partners of ADC Review / Journal of Antibody-drug Conjugates. He is also a member of the journal’s Editorial Advisory Board.
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