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Unfolding (protein)

The correct three-dimensional structure of a protein is essential for its proper function. Failure to form a highly ordered and tightly folded native structure generally produces inactive proteins, but in some instances misfolded proteins have modified or toxic functionality. Protein unfolding refers to a form of protein degradation in which the three-dimensional structure of the protein molecule unravels to something that resembles a basic chain of amino acids.

Unfolded proteins adopt a largely disordered structure.

See Denaturants


Vinca alkaloids

Vinca alkaloids are a class of microtubule inhibitor that prevent polymerization of microtubules by blocking the region involved in tubulin dimer attachment. They have also been shown to induce apoptosis in some solid tumors.


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