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NCT02487979 (Clinical Trial / Glembatumumab vedotin / CDX-011 / CR011-vcMMAE)

Study Title
Glembatumumab Vedotin in Treating Patients With Recurrent or Refractory Osteosarcoma (NCT02487979)

Trial Description
This phase II trial studies how well glembatumumab vedotin works in treating patients with osteosarcoma that has come back (recurrent) or does not respond to treatment (refractory). Antibody drug conjugates, such as glembatumumab vedotin (also known as CDX-011 or CR011-vcMMAE), provide treatment with injections of therapeutic substances linked with specific antibodies in order to directly destroy tumor cells or to stimulate the immune system to destroy those cells.

This trial is sponsored by the National Cancer Institute (NCI). [1]

Study Data

  • Condition: Osteosarcoma
  • Interventions:
    • Drugs used in this trial
      • Glembatumumab Vedotin (CDX-011; CR011-vcMMAE)
    • Other:
      • Laboratory Biomarker Analysis
      • Pharmacological Study
  • Phase: II
  • Estimated Enrollment: 38
  • Start: August 2015
  • Last verified: June 2015

Study Schematic 

(Coming soon)


Last Editorial review: September 29, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.

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