20 November, 2018
Single-use technology, designed for the manufacturing of biopharmaceutical products, has made major inroads over the last 30 years. First introduced in the late 1970s in the form of disposable capsules and a ...
Brentuximab Vedotin Associated With Chemotherapy in Untreated Patients With Hodgkin Lymphoma. (BREACH)(NCT02292979)
This study aims to evaluate the efficacy of brentuximab vedotin + AVD combination (doxorubicine, vinblastine, dacarbazine) in patients with Hodgkin lymphoma stage I / II with an unfavorable diagnosis, assessed by the negativity of PET (positron emission tomography) after two cycles of chemotherapy.
The BREACH (also known as LYSA/FIL/EORTC-20113) study in early stage HL patients, incorporating the anti -CD30 conjugate brentuximab vedotin in first-line treatment of unfavorable CSI/II disease (AVD-Br vs ABVD, followed by involved node radiotherapy or INRT). The primary goal is to improve the PET negativity after two cycles of chemotherapy. Next to the more common secondary end points (PFS, OS, CR rate after 2 cycles), researchers are very interested in the toxicity pattern of brentuximab vedotin in combination therapy.
This trial is sponsored by The Lymphoma Academic Research Organization (LYSARC) 
Last Editorial review: July 15, 2016
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.
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20 November, 2018
05 October, 2018
When the first antibody-drug conjugate (ADC) was approved by the U.S. Food and Drug Administration (FDA) in 2000, only a handful of patent applications claiming ADCs had been published. As research cont...