20 November, 2018
Single-use technology, designed for the manufacturing of biopharmaceutical products, has made major inroads over the last 30 years. First introduced in the late 1970s in the form of disposable capsules and a ...
A Study to Evaluate the Safety and Pharmacology of DNIB0600A in Patients With Ovarian Cancer (NCT01995188)
This open-label, multicenter, phase Ib study will evaluate the safety and pharmacokinetics of DNIB0600A ( also known as lifastuzumab vedotin / anti-NaPi2b ADC / RG-7599 / DNIB0600A) in patients with platinum-sensitive ovarian cancer. The maximum tolerated dose of intravenously infused DNIB0600A in combination with carboplatin will be determined in escalating dose cohorts. The combination of DNIB0600A and carboplatin will then be evaluated with and without bevacizumab [Avastin] in two dose expansion cohorts.
This trial is sponsored by Genentech. 
Last Editorial review: July 10, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.
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20 November, 2018
05 October, 2018
When the first antibody-drug conjugate (ADC) was approved by the U.S. Food and Drug Administration (FDA) in 2000, only a handful of patent applications claiming ADCs had been published. As research cont...