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NCT01700751 (Clinical Trial / Brentuximab Vedotin / SGN-035)

Study Title
Brentuximab Vedotin Prevention of (GVHD) After Unrelated Allogeneic Stem Cell Transplantation (NCT01700751)

Trial Description
This pilot clinical trial studies the safety and maximum tolerated dose of brentuximab vedotin (also known as SGN-035) when given with the immunosuppressive drug tacrolimus (Protopic®; Astellas Pharma US) and methotrexate after unrelated allogeneic donor stem cell transplant in patients with acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndromes. The addition of brentuximab vedotin to tacrolimus and methotrexate may result in a significant reduction of graft versus host disease in these patients.

This trial is sponsored by Washington University School of Medicine. [1]

Study Data

  • Condition: Leukemia, Myelodysplastic Syndromes
  • Interventions:
  • Phase: 0
  • Estimated Enrollment: 17
  • Start: February 2013
  • Estimated Completion: August 2017
  • Last verified: January 2014

Study Schemata

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Last Editorial review: July 6, 2016
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.

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