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NCT00551460 (Clinical Trial / Gemtuzumab Ozogamicin)

Study Title
S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia (NCT00551460)

Trial Description
Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibody-drug conjugates or ADCs, such as gemtuzumab ozogamicin (Mylotarg®; Pfizer/Wyeth-Ayerst Laboratories), can block cancer growth in different ways. Some find cancer cells and help kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread.

Gemtuzumab ozogamicin may also stop the growth of promyelocytic leukemia by blocking blood flow to the cancer. Giving gemtuzumab ozogamicin together with combination chemotherapy may be more effective in treating promyelocytic leukemia.

This phase II trial is studying how well giving gemtuzumab together with combination chemotherapy works in treating patients with previously untreated promyelocytic leukemia

This trial is sponsored by Southwestern Oncology GroupNational Cancer Institute (NCI). [1]

Study Data

Study Schematic

(Coming soon)

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Last Editorial review: July 22, 2015
Information based on ClinicalTrials.gov (NIH/NCI) and other sources.

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